Custom Peptides
Cayman Chemical ShnzhIsIde methyl ester 10mg
An iridoid glycoside with anti-inflammatory and antinociceptive activities; a GLP-1R agonist; inhibits the release of MPO and elastase from fMLP-activated isolated rat neutrophils at 10 µM; inhibits LPS-induced increases in the release of IL-8 and LTB4 from isolated rat neutrophils at 10 µM; reduces L5/L6 spinal nerve ligation-induced mechanical allodynia in rats (ED50 = 40.4 UG/animal)
Immunology Consultants anti-Glu-Glu Antibody (Rabbit) - Affinity Purified
RGLU‑45A‑Z offers the same high‑performance affinity‑purified anti‑Glu‑Glu antibody as RGLU‑45A but in a 0.1 mg format ideal for small‑scale or pilot‑scale studies. This reagent provides strong, selective binding to the Glu‑Glu epitope and performs reliably in Western blotting, ELISA, and immunoprecipitation workflows. Produced by Immunology Consultants, RGLU‑45A‑Z is a cost‑effective option for laboratories requiring a smaller quantity of a high‑purity anti‑Glu‑Glu antibody.
Cayman Chemical GlycInmurIcholIc AcId 10mg
An intestine-selective FXR antagonist; glycine-conjugated form of β-muricholic acid; inhibits chenodeoxycholic acid- and GW 4064-induced expression of the FXR target genes Shp and Fgf15 at 100 μM; resistant to hydrolysis by fecal BSH isolated from gut microbiota; decreases Shp and Fgf15 mRNA expression in ileum, but not liver, and reduces ceramide levels and expression of various ceramide synthesis-related genes in ileum of mice with high-fat diet-induced obesity and db/db mice at 10 mg/kg; prevents weight gain, reduces blood glucose levels, and increases insulin sensitivity as well as prevents development of cholestasis and necrotic lesions in liver of mice with high-fat diet-induced obesity
Cayman Chemical NorgestImate 10mg
A progestin; prodrug form of norelgestromin and levonorgestrel; binds to progestin receptors (mean IC50 = 3.48 nM for rabbit uterine receptors) and is selective for progestin over androgen receptors (mean IC50 = 764 nM for rat prostatic receptors); maintains pregnancy in ovariectomized female rats in a dose-dependent manner; inhibits ovulation in 100% of female rats at 0.5 mg/kg; completely inhibits estrone-induced vaginal cornification in ovariectomized female rats at 2 mg/kg, indicating antiestrogenic activity
Cayman Chemical BepotastInbesylate 10mg
A histamine H1 receptor antagonist; selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors; reduces dye leakage from the nasal passages of sensitized rats (ED50 = 0.03 mg/kg); inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 UG/kg); dose-dependently prevents conjunctival vascular hyperpermeability a in guinea pig model of conjunctivitis
Cayman Chemical AspartylalnyldIketopIpRaz 10mg
An immunosuppressive diketopiperazine derivative of an HSA peptide; reduces antigen-induced TNF-α and IFN-γ production in isolated human T cells at 500 µM
Cayman Chemical 15-keto ProstaglndIn F2a 10mg
First metabolite of PGF2α in the 15-hydroxy PGDH pathway; a critical component in the goldfish and Atlantic salmon postovulatory pheromone
Cayman Chemical TryptnthrIn 10mg
An alkaloid originally found to have antimicrobial actions; both 5-LO and COX-2 (IC50s = 600 and 64 nM, respectively); suppresses angiogenesis, blocking signaling through VEGFR2 at the level of ERK1/2 signaling; prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity
Cayman Chemical UlIxertInIbhydrochlorIde 10mg
A reversible ERK1/2 inhibitor (IC50 50 value of 180 nM
Cayman Chemical CInacIguathydrochlorIde 10mg
An activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM); reduces hypertension, limits cardiomyocyte hypertrophy, protects against ischemia/reperfusion injury, and reduces morbidity and mortality in response to endotoxic shock
Cayman Chemical ApomorphInhydrochlorId 10mg
A non-selective dopamine receptor agonist (pKis = 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively); produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions
Cayman Chemical 5fluoro PB22 3hdroxquIno 10mg
Differs from 5-fluoro PB-22 by having the ester linkage inserted at the three, rather than at the eight, position of the quinoline moiety; intended for forensic and research purposes
![Cayman Chemical Guanosine 5'-[-thio]triphosphate (lithium salt) 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502911527.png-250.jpg)
Cayman Chemical Guanosine 5'-[-thio]triphosphate (lithium salt) 10mg
A hydrolysis-resistant analog of GTP; binds to and activates G proteins in the presence of magnesium; has been used to obtain crystal structures of GTPases in their active states, as well as measure the stability of GTPases in the presence of ligands; [35S]GTPγS is commonly used in binding assays to determine agonism or antagonism at GPCRs
Cayman Chemical Latnoprost 10mg
An FP receptor agonist and prodrug of latanoprost (free acid); induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells, HEK293 cells expressing human ocular FP receptors, mouse NIH3T3 fibroblasts, and rat A7r5 vascular smooth muscle cells (EC50s = 313, 564, 173, 142, and 110 nM, respectively); topical ocular application reduces IOP in cynomolgus monkeys in a model of laser-induced glaucoma at 0.005% twice per day
Cayman Chemical Benzonatte 10mg
A voltage-gated sodium channel blocker; blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively); blocks 80% of Nav1.3 currents in N1E-115 cells (100 μM); reduces the frequency of the cough reflex in anesthetized dogs